Frances Elisabeth Crowell was born on May 10, 1880 in Pittsfield, Massachusetts. After completing extensive training as a nurse, in 1896 she became part owner and superintendent of Pensacola Infirmary in Florida, now known as St. Anthony's Hospital.
In 1905 she moved to New York to complete her social work education at the New York School of Philanthropy. While working with the Association of Neighborhood Workers she made significant contributions to public health through her studies on midwifery from 1906-1917. She also served as Executive Secretary of the Association of Tuberculosis Clinics.
Her work in this area took her to Europe where, as a member of the International Health Board, she began working on the Rockefeller Foundation's Commission for the Prevention of Tuberculosis. Here she started nursing education programs, bringing her recognition as one of the most important people contributing to modern European nursing.
She retired from the Foundation on May 31, 1940, but went on to serve as advisor for the American Red Cross in Italy where she died February 11, 1950 in Santa Margharita.